Monthly Archives: May 2023

The CLIMB Study Breast cancer remains a significant health concern for older women, who account for appoximately 50% of those diagnosed with the condition. Older patients often have reduced physiological reserve and clinically significant comorbidities, and are more susceptible to both undertreatment and to overtreatment, as well as being more likely to experience treatment toxicity and early discontinuation of therapy. Around 70-80% of breast cancers are categorized as estrogen-receptor (ER) positive. Regardless of the disease stage or setting, a majority of patients diagnosed with ER+ cancers are likely, at some point during their treatment course, to be treated with endocrine therapy (ET), which works to block or prevent estrogen signaling, and is typically taken for between five to ten years in the adjuvant setting. In general, ET comes in one of two forms, either aromatase inhibitors (AI), such as exemestane and letrozole, or selective estrogen receptor modulators (SERMs) such as [...]