Published Guidelines
SIOG Clinical Practice Guidelines are intended to provide the user with a set of recommendations for the best standards of cancer care in older adults, based on the findings of evidence-based medicine. Published SIOG Guidelines are available below on the following topics:
- Acute Myeloid Leukemia (AML)
- Breast Cancer
- Comormidities
- COVID-19
- Gastrointestinal Cancers
- Genitourinary Cancers
- Geriatric Assessment
- Hematologic Malignancies
- NSCLC
- Quality of Life
- Radiotherapy
- Skin Cancer
- Supportive Care
- Surgery
- Systemic Therapy
- Others
Guidelines under Development
SIOG Clinical Practice Guidelines are under development on the following topics:
- Autologous stem cell transplantation for multiple myeloma patients
- CGA interventions in older patients with cancer
- Corticosteroid therapy in the older cancer patient: Expert recommendations from SIOG
- Immunotherapy in older adults
- Lung cancer screening
- Management of lung cancer in older patients
- Radiation therapy
- Treatment of ovarian cancer in older adults – Development of treatment algorithms and educational programs
- Update on the management of prostate cancer in older cancer patients
Published Guidelines
Breast Cancer
- Biganzoli L, Battisti NM, Wildiers H, McCartney A, Colloca G, Kunkler IH, Cardoso MJ, Cheung KL, De Glas NA, Trimboli RM, Korc-Grodzicki B. Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG). The Lancet Oncology. 2021 Jul 1;22(7):e327-40.
- Brain E, Caillet P, de Glas N, Biganzoli L, Cheng K, Dal Lago L, Wildiers H. HER2-targeted treatment for older patients with breast cancer: An expert position paper from the International Society of Geriatric Oncology. Journal of geriatric oncology. 2019 Nov 1;10(6):1003-13.
- Battisti NM, De Glas N, Sedrak MS, Loh KP, Liposits G, Soto-Perez-de-Celis E, Krok-Schoen JL, Menjak IB, Ring A. Use of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in older patients with ER-positive HER2-negative breast cancer: Young International Society of Geriatric Oncology review paper. Therapeutic Advances in Medical Oncology. 2018 Nov;10:1758835918809610.
- Biganzoli L, Aapro M, Loibl S, Wildiers H, Brain E. Taxanes in the treatment of breast cancer: Have we better defined their role in older patients? A position paper from a SIOG Task Force. Cancer Treatment Reviews. 2016 Feb 1;43:19-26.
- Biganzoli L, Wildiers H, Oakman C, Marotti L, Loibl S, Kunkler I, Reed M, Ciatto S, Voogd AC, Brain E, Cutuli B. Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). The lancet oncology. 2012 Apr 1;13(4):e148-60.
- Wildiers H, Kunkler I, Biganzoli L, Fracheboud J, Vlastos G, Bernard-Marty C, Hurria A, Extermann M, Girre V, Brain E, Audisio RA. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. The lancet oncology. 2007 Dec 1;8(12):1101-15.
COVID-19
- Mislang AR, Soto-Perez-de-Celis E, Russo C, Colloca G, Williams GR, O’Hanlon S, Cooper L, O’Donovan A, Audisio RA, Cheung KL, Sarrió RG. The SIOG COVID-19 working group recommendations on the rollout of COVID-19 vaccines among older adults with cancer. Journal of Geriatric Oncology. 2021 Jun 1;12(5):848-50.
- Battisti NM, Mislang AR, Cooper L, O’Donovan A, Audisio RA, Cheung KL, Sarrió RG, Stauder R, Soto-Perez-de-Celis E, Jaklitsch M, Williams GR. Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group. Journal of geriatric oncology. 2020 Nov 1;11(8):1190-8.
Gastrointestinal Cancers
- Papamichael D, Lopes GS, Olswold CL, Douillard JY, Adams RA, Maughan TS, Van Cutsem E, Venook AP, Lenz HJ, Heinemann V, Kaplan R. Efficacy of anti-epidermal growth factor receptor agents in patients with RAS wild-type metastatic colorectal cancerá≥ 70 years. European Journal of Cancer. 2022 Mar 1;163:1-5.
- Mottet N, Ribal MJ, Boyle H, De Santis M, Caillet P, Choudhury A, Garg T, Nielsen M, Wüthrich P, Gust KM, Shariat SF. Management of bladder cancer in older patients: Position paper of a SIOG Task Force. Journal of geriatric oncology. 2020 Sep 1;11(7):1043-53.
- Montroni I, Ugolini G, Saur NM, Spinelli A, Rostoft S, Millan M, Wolthuis A, Daniels IR, Hompes R, Penna M, Fürst A. Personalized management of elderly patients with rectal cancer: expert recommendations of the European Society of Surgical Oncology, European Society of Coloproctology, International Society of Geriatric Oncology, and American College of Surgeons Commission on Cancer. European Journal of Surgical Oncology. 2018 Nov 1;44(11):1685-702.
- Mislang AR, Di Donato S, Hubbard J, Krishna L, Mottino G, Bozzetti F, Biganzoli L. Nutritional management of older adults with gastrointestinal cancers: an International Society of Geriatric Oncology (SIOG) review paper. Journal of geriatric oncology. 2018 Jul 1;9(4):382-92.
- Papamichael D, Audisio RA, Glimelius B, de Gramont A, Glynne-Jones R, Haller D, Köhne CH, Rostoft S, Lemmens V, Mitry E, Rutten H. Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013. Annals of oncology. 2015 Mar 1;26(3):463-76.
- Papamichael D, Audisio R, Horiot JC, Glimelius B, Sastre J, Mitry E, Van Cutsem E, Gosney M, Köhne CH, Aapro M. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Annals of oncology. 2009 Jan 1;20(1):5-16.
Genitourinary Cancers
- Boyle HJ, Alibhai S, Decoster L, Efstathiou E, Fizazi K, Mottet N, Oudard S, Payne H, Prentice M, Puts M, Aapro M. Updated recommendations of the International Society of Geriatric Oncology on prostate cancer management in older patients. European Journal of Cancer. 2019 Jul 1;116:116-36.
- Kanesvaran R, Le Saux O, Motzer R, Choueiri TK, Scotté F, Bellmunt J, Launay-Vacher V. Elderly patients with metastatic renal cell carcinoma: position paper from the International Society of Geriatric Oncology. The Lancet Oncology. 2018 Jun 1;19(6):e317-26.
- Droz JP, Albrand G, Gillessen S, Hughes S, Mottet N, Oudard S, Payne H, Puts M, Zulian G, Balducci L, Aapro M. Management of prostate cancer in elderly patients: recommendations of a task force of the International Society of Geriatric Oncology. European urology. 2017 Oct 1;72(4):521-31.
- Prior JO, Gillessen S, Wirth M, Dale W, Aapro M, Oyen WJ. Radiopharmaceuticals in the elderly cancer patient: Practical considerations, with a focus on prostate cancer therapy: A position paper from the International Society of Geriatric Oncology Task Force. European Journal of Cancer. 2017 May 1;77:127-39.
- Droz JP, Aapro M, Balducci L, Boyle H, Van den Broeck T, Cathcart P, Dickinson L, Efstathiou E, Emberton M, Fitzpatrick JM, Heidenreich A. Management of prostate cancer in older patients: updated recommendations of a working group of the International Society of Geriatric Oncology. The lancet oncology. 2014 Aug 1;15(9):e404-14.
- Droz JP, Balducci L, Bolla M, Emberton M, Fitzpatrick JM, Joniau S, Kattan MW, Monfardini S, Moul JW, Naeim A, Van Poppel H. Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology. BJU international. 2010 Aug;106(4):462-9.
- Bellmunt J, Négrier S, Escudier B, Awada A, Aapro M. The medical treatment of metastatic renal cell cancer in the elderly: position paper of a SIOG Taskforce. Critical reviews in oncology/hematology. 2009 Jan 1;69(1):64-72.
Geriatric Assessment
- Burhenn PS, McCarthy AL, Begue A, Nightingale G, Cheng K, Kenis C. Geriatric assessment in daily oncology practice for nurses and allied health care professionals: Opinion paper of the Nursing and Allied Health Interest Group of the International Society of Geriatric Oncology (SIOG). Journal of geriatric oncology. 2016 Sep 1;7(5):315-24.
- Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, Falandry C, Artz A, Brain E, Colloca G, Flamaing J. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. Journal of clinical oncology. 2014 Aug 8;32(24):2595.
- Decoster L, Van Puyvelde K, Mohile S, Wedding U, Basso U, Colloca G, Rostoft S, Overcash J, Wildiers H, Steer C, Kimmick G. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Annals of Oncology. 2015 Feb 1;26(2):288-300.
- Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Lichtman S, Mor V, Monfardini S, Repetto L, Sørbye L, Topinkova E. Use of comprehensive geriatric assessment in older cancer patients:: Recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Critical reviews in oncology/hematology. 2005 Sep 1;55(3):241-52.
Hematologic Malignancies
- Klepin HD, Neuendorff NR, Larson RA, Hamaker ME, Breccia M, Montesinos P, Cordoba R. Treatment of acute promyelocytic leukemia in older patients: recommendations of an International Society of Geriatric Oncology (SIOG) task force. Journal of Geriatric Oncology. 2020 Nov 1;11(8):1199-209.
- Stauder R, Eichhorst B, Hamaker ME, Kaplanov K, Morrison VA, Österborg A, Poddubnaya I, Woyach JA, Shanafelt T, Smolej L, Ysebaert L. Management of chronic lymphocytic leukemia (CLL) in the elderly: a position paper from an international Society of Geriatric Oncology (SIOG) Task Force. Annals of Oncology. 2017 Feb 1;28(2):218-27.
- Morrison VA, Hamlin P, Soubeyran P, Stauder R, Wadhwa P, Aapro M, Lichtman S. Diffuse large B-cell lymphoma in the elderly: impact of prognosis, comorbidities, geriatric assessment, and supportive care on clinical practice. An International Society of Geriatric Oncology (SIOG) expert position paper. Journal of geriatric oncology. 2015 Mar 1;6(2):141-52.
Supportive Care
- Body JJ, Terpos E, Tombal B, Hadji P, Arif A, Young A, Aapro M, Coleman R. Bone health in the elderly cancer patient: a SIOG position paper. Cancer treatment reviews. 2016 Dec 1;51:46-53.
- Body JJ, Coleman R, Clezardin P, Ripamonti C, Rizzoli R, Aapro M. International Society of Geriatric Oncology (SIOG) clinical practice recommendations for the use of bisphosphonates in elderly patients. European Journal of Cancer. 2007 Mar 1;43(5):852-8.
Surgery
- Ghignone F, Van Leeuwen BL, Montroni I, Huisman MG, Somasundar P, Cheung KL, Audisio RA, Ugolini G. The assessment and management of older cancer patients: a SIOG surgical task force survey on surgeons’ attitudes. European Journal of Surgical Oncology (EJSO). 2016 Feb 1;42(2):297-302.
- Kristjansson SR, Spies C, Veering BT, Silverstein JH, Vigano AA, Mercadante S, Jack S, Zaniboni A, Schmidt M, Watt HL, Grocott MP. Perioperative care of the elderly oncology patient: a report from the SIOG task force on the perioperative care of older patients with cancer. Journal of Geriatric Oncology. 2012 Apr 1;3(2):147-62.
- Audisio RA. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help A SIOG surgical task force prospective study. Critical Reviews in Oncology and Hematology. 2008 Feb 1.
- Audisio RA, Bozzetti F, Gennari R, Jaklitsch MT, Koperna T, Longo WE, Wiggers T, Zbar AP. The surgical management of elderly cancer patients: recommendations of the SIOG surgical task force. European Journal of Cancer. 2004 May 1;40(7):926-38.
Systemic Therapy
- Liposits G, Loh KP, Soto-Perez-de-Celis E, Dumas L, Battisti NM, Kadambi S, Baldini C, Banerjee S, Lichtman SM. PARP inhibitors in older patients with ovarian and breast cancer: Young International Society of Geriatric Oncology review paper. Journal of geriatric oncology. 2019 Mar 1;10(2):337-45.
- Mislang AR, Wildes TM, Kanesvaran R, Baldini C, Holmes HM, Nightingale G, Coolbrandt A, Biganzoli L. Adherence to oral cancer therapy in older adults: the International Society of Geriatric Oncology (SIOG) taskforce recommendations. Cancer treatment reviews. 2017 Jun 1;57:58-66.
- Biganzoli L, Lichtman S, Michel JP, Papamichael D, Quoix E, Walko C, Aapro M. Oral single-agent chemotherapy in older patients with solid tumours: a position paper from the International Society of Geriatric Oncology (SIOG). European journal of cancer. 2015 Nov 1;51(17):2491-500.
- Aapro M, Bernard-Marty C, Brain EG, Batist G, Erdkamp F, Krzemieniecki K, Leonard R, Lluch A, Monfardini S, Ryberg M, Soubeyran P. Anthracycline cardiotoxicity in the elderly cancer patient: a SIOG expert position paper. Annals of Oncology. 2011 Feb 1;22(2):257-67.
- Lichtman SM, Wildiers H, Chatelut E, Steer C, Budman D, Morrison VA, Aapro M. International Society of Geriatric Oncology (SIOG) Chemotherapy Taskforce evaluation of chemotherapy in older patients: An analysis of the medical literature. J Clin Oncol. 2007;25(1832):2007-1843.
- Lichtman SM, Wildiers H, Launay-Vacher V, Steer C, Chatelut E, Aapro M. International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. European journal of cancer. 2007 Jan 1;43(1):14-34.
Others
- Wildiers H, Mauer M, Pallis A, Hurria A, Mohile SG, Luciani A, Curigliano G, Extermann M, Lichtman SM, Ballman K, Cohen HJ. End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer–Alliance for Clinical Trials in Oncology–International Society Of Geriatric Oncology position article. Journal of Clinical Oncology. 2013 Oct 10;31(29):3711-8.
- Monfardini S, Aapro MS, Bennett JM, Mori M, Regenstreif D, Rodin M, Stein B, Zulian GB, Droz JP. Organization of the clinical activity of geriatric oncology: report of a SIOG (International Society of Geriatric Oncology) task force. Critical reviews in oncology/hematology. 2007 Apr 1;62(1):62-73.
- Surbone A, Kagawa-Singer M, Terret C, Baider L. The illness trajectory of elderly cancer patients across cultures: SIOG position paper. Annals of Oncology. 2007 Apr 1;18(4):633-8.