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Diffuse Large B-Cell Lymphoma in the Elderly Task Force

Background: Non-Hodgkin’s lymphoma (NHL) is a common malignancy in both males and females. Of interest is that over the past two decades, the incidence of this disorder has been increasing across all adult age groups, rising by as much as 8-10% per year, and especially in patients >60 years of age. This increasing incidence is relevant in the elderly population; while patients age > 65 years represent 13% of the population, 53% of all new cases occur in this age group. The median age of patients at NHL diagnosis is 67 years. With the population >75 years and 85 years of age tripling and doubling, respectively, by 2030, the occurrence of NHL in this older patient population will pose an increasing problem. Diffuse large B-cell NHL (DLBCL) is one of the common subtypes of NHL diagnosed in the elderly population. Treatment of this disorder, which generally includes anthracycline-based combination chemotherapy, is complicated by comorbidities, as well as alterations in functional status, in the older population. Fortunately, in the past decade, the elderly population with DLBCL has been extensively studied in prospective clinical treatment trials, resulting in advances in the therapy of these patients.

Objectives: The aim of this proposed position / expert opinion paper is to develop an International Society of Geriatric Oncology (SIOG)-based expert guideline on the care of older patients with DLBCL. This guideline will address diagnosis, geriatric evaluation, staging, prognosis, and treatment recommendations in the untreated and salvage settings, but will also provide guidance for the supportive care management of these patients.

Task Force Members

Chair: Vicki Morrison, USA
Writing Committee
Paul Hamlin, USA
Reinhard Stauder, Austria
Stu Lichtman, USA
Pierre Soubeyran, France
Punit Wadhwa, USA
Ulrich Wedding, Germany

Reviewing Committee
Catherine Terret, France
Gilbert Zulian, Switzerland
Lodovico Balducci, USA
Irina Poddubnaya, Russia
Gayane Tumyan, Russia

Publications

2015
The following manuscript was published by the Annals of Oncology. Approach to therapy of diffuse large B-cell lymphoma in the elderly: the International Society of Geriatric Oncology (SIOG) expert position commentary. Morrison VA, Hamlin P, Soubeyran P, Stauder R, Wadhwa P, Aapro M, Lichtman SM. Ann Oncol. 2015 Jan 29. pii: mdv018. [Epub ahead of print]

2014
The following manuscript was published by the Journal of Geriatric Oncology (JGO). Diffuse large B-cell lymphoma in the elderly: Impact of prognosis, comorbidities, geriatric assessment, and supportive care on clinical practice. An International Society of Geriatric Oncology (SIOG) Expert Position Paper. Morrison VA, Hamlin P, Soubeyran P, Stauder R, Wadhwa P, Aapro M, Lichtman S. J Geriatr Oncol. 2014 Dec 7. pii: S1879-4068(14)00357-9. doi: 10.1016/j.jgo.2014.11.004. [Epub ahead of print]

This project was supported by unrestricted grants from Teva and Astellas.