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ESH is organizing its 4th International Conference on Hematologic Malignancies at Older Age: Biology and Therapy, which will take place on March 9-11, 2018 in Mandelieu (France) under the scientific direction of Bob Löwenberg, Benjamin Ebert, Pierre Fenaux, and Michael Hallek.

The program of this conference will deal with the evolution of the hematopoietic system during aging, how this evolution contributes to the development of hematological malignancies, most of which predominate in the elderly as well as the diagnosis and therapeutic management of myeloid and lymphoid hematologic malignancies at older age.

For instance, the occurrence of somatic mutations in myeloid cells appear to be early steps in the pathophysiology of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), and epigenetic changes and bone marrow stroma modi­ cations occurring with aging may have a pathogenetic role in this development. Clonal B lymphocytosis and monoclonal gammopathies, mainly seen in the elderly, represent early phases of chronic lymphocytic leukemia (CLL) and myeloma, respectively. Aging of the immune system contributes to the higher rate of infections seen in elderly subjects.

The program will explore potential intrinsic speci­fic characteristics of hematological malignancies as they present in patients of older age, in comparison to younger patients, and discuss the therapeutic management and specific requirements in older patients.

Special attention will be given to the utility and promise of new drugs, especially targeted drugs with reduced or no myelosuppression, that may be particularly useful in elderly patients to analyze a frequent situation in the elderly, ie anemia.

Download the programme